HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (E)-1-(6-Fluoropyridin-2-yl)-2-styryl-1H-benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,6-Difluoropyridine | HCID 73934 | — |
| Reactant | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (E)-1-(6-Fluoropyridin-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736651 | — |
Reaction Steps
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2,6-difluoropyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was dissolved into diethyl ether and hydrogen chloride gas was passed through the ether solution. Filtration and drying under vacuum yielded the titled compound as pale yellow solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-ef78539839944a299c0bd525feca73c0 |
| Source note | uspto-grants-2001_10 |