HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (E)-1-(6-Chloro4-pyrimidyl)-2-styryl-1H-benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (E)-1-(6-Chloro4-pyrimidyl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736683 | — |
Reaction Steps
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 4,6-dichloropyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-87f35a9fe33a453d8d66663ed07eded4 |
| Source note | uspto-grants-2001_10 |