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Hydrochloric Acid → (E)-2-(2-Methylstyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| 反応物 | (e)-3-o-Tolylacryloyl chloride | HCID 5706558 | — |
| 反応物 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (E)-2-(2-Methylstyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 22736767 | — |
反応手順
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-2-methylcinnamoyl chloride (Sekiya, T.; Hiranuma, H.; Hata, S.; Mizogami, S.; Hanazuka, M.; Yamada, S. J. Med. Chem., 1983, 26, 411) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310079B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-11fe2b11e1ad46baac03753b90389e95 |
| 出典メモ | uspto-grants-2001_10 |