HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 22736668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| Reactant | (2E)-3-(2-Chlorophenyl)-2-propenoyl chloride | HCID 5702880 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22736668 | HCID 22736668 | — |
Reaction Steps
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and (E)-2-chlorocinnamoyl chloride (Amino, Y.; Kawada, K.; Toi, K.; Kumashiro, I.; Fukushima, K. Chem. Pharm. Bull., 1988, 36, 4426) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-30de4535e44a4ae48cccd700acc8267e |
| Source note | uspto-grants-2001_10 |