HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Reactant | 3,4-Dimethoxycinnamoylchloride | HCID 53399206 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate | HCID 69914538 | — |
Reaction Steps
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 3,4-dimethoxycinnamoyl chloride (Ramamurthy, B.; Sugumaran, M. Synthesis, 1987, 523) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-703a92826bf54efe8e7f23d7dcd68d88 |
| Source note | uspto-grants-2001_10 |