HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (E)-2-(3-Methyl-1-butenyl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N1-(pyridin-2-yl)benzene-1,2-diamine | HCID 752150 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Reactant | 4-Methyl-2-pentenoyl chloride | HCID 54170063 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (E)-2-(3-Methyl-1-butenyl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 22736743 | — |
Reaction Steps
Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 4-methyl-2-pentenoyl chloride (Yamada, T.; Takashima, K.; Miyazawa, T.; Kuwata, S.; Watanabe, H. Bull. Chem. Soc. Jpn. 1978, 51, 878) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-b40bf3b11c6f4d01a610b87774c36c88 |
| Source note | uspto-grants-2001_10 |