HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → [4-chloro-2-[4-(phenylsulfonyl)-1-piperazinylmethyl]phenoxy]-acetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | [4-chloro-2-(1-piperazinylmethyl)phenoxy]-acetic Acid, Ethyl Ester | HCID 86631054 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | [4-chloro-2-[4-(phenylsulfonyl)-1-piperazinylmethyl]phenoxy]-acetic Acid | HCID 53317503 | — |
Reaction Steps
The product of example 11 part b (300 mg) was dissolved in THF (10 ml) and triethylamine (0.28 ml). The sulfonyl chloride (1.1 equivalents) was added and stirred for 3 h. 1M NaOH (3 ml) was added and stirred for 2 hours. Acetic acid (5 ml) was added and then the reaction mixture was concentrated in vacuo. The residue was further purified by RPHPLC to give the sub-title compound (0.19 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524715B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-5690df7e4f7f479abd9a68ea786d760c |
| Source note | uspto-grants-2013_09 |