HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → (E)-1-(2-Pyridyl)-2-styryl-5-methoxy-1H-benzimidazole oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 4-Methoxy-2-nitroaniline | HCID 66793 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole | HCID 22736704 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (E)-1-(2-Pyridyl)-2-styryl-5-methoxy-1H-benzimidazole oxalate | HCID 22736663 | — |
Reaction Steps
Free base of the titled compound was prepared from 4-methoxy-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-5872926846fe4492bb50038949309a5a |
| Source note | uspto-grants-2001_10 |