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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 382571Generated: October 25, 2026

Oxalic Acid → (E)-6-Methoxy-1-(2-pyridyl)-2-styryl-1H-benzimidazole oxalate

https://huagongshe.com/reaction/382571

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxalic AcidHCID 971—
Reactant5-Methoxy-2-nitroanilineHCID 85300—
Reactant(E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazoleHCID 22736704—
SolventEthyl AcetateHCID 8857—
Product(E)-6-Methoxy-1-(2-pyridyl)-2-styryl-1H-benzimidazole oxalateHCID 22736778—

Reaction Steps

Free base of the titled compound was prepared from 5-methoxy-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06310079B1
Source datasetuspto-grants-2001_10
ORD IDord-e9571cf57b554fc596f4c3537d17d1f1
Source noteuspto-grants-2001_10