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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 382577Generated: October 26, 2026

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole → (E)-2-[2-(Cyclohexyl)ethenyl]-5-fluoro-1-(2-pyridyl)-1H-benzimidazole

https://huagongshe.com/reaction/382577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 9796241—
Reactant(E)-3-cyclohexylacryloyl chlorideHCID 12542153—
Reactant4-fluoro-2-amino-N-(2-pyridyl)anilineHCID 22736745—
Product(E)-2-[2-(Cyclohexyl)ethenyl]-5-fluoro-1-(2-pyridyl)-1H-benzimidazoleHCID 9883594—

Reaction Steps

The titled compound was prepared from 4-fluoro-2-amino-N-(2-pyridyl)aniline and (E)-3-cyclohexylacryloyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06310079B1
Source datasetuspto-grants-2001_10
ORD IDord-c06fdbf6385349ada04c8fa801fb6f31
Source noteuspto-grants-2001_10