(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole → (E)-5-Fluoro-2-[2-(3-furyl)ethenyl]-1-(2-pyridyl)-1H-benzimidazole

HRID 382578Notes

Reaction equation

HRID 382578 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([NH:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)=[C:4]([NH2:15])[CH:3]=1.[O:16]1[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23](Cl)=O)=[CH:17]1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1>>[F:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)[C:23](/[CH:22]=[CH:21]/[C:18]3[CH:19]=[CH:20][O:16][CH:17]=3)=[N:15][C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 22736687(E)-3-(Furan-3-yl)acryloyl chlorideHCID 227367454-fluoro-2-amino-N-(2-pyridyl)aniline

Product 1

HCID 22736678(E)-5-Fluoro-2-[2-(3-furyl)ethenyl]-1-(2-pyridyl)-1H-benzimidazole

Procedure

The titled compound was prepared from 4-fluoro-2-amino-N-(2-pyridyl)aniline and (E)-3-(3-furyl)acryloyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A).

Sources & evidence

ORD record
ord-c0987fcd29f64b32b92a23eadcb22c25
Source dataset
uspto-grants-2001_10
Patent number
US06310079B1

Reaction notes

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