HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → (E)-5-Fluoro-1-(2-pyridyl)-2-[2-(2-thienyl)ethenyl]-1H-benzimidazole oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Reactant | 3-(2-Thienyl)acryloyl chloride | HCID 11263780 | — |
| Reactant | 4-fluoro-2-amino-N-(2-pyridyl)aniline | HCID 22736745 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (E)-5-Fluoro-1-(2-pyridyl)-2-[2-(2-thienyl)ethenyl]-1H-benzimidazole oxalate | HCID 22736676 | — |
Reaction Steps
Free base of the titled compound was prepared from 4-fluoro-2-amino-N-(2-pyridyl)aniline and (E)-3-(2-thienyl)acryloyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-9dd81abf149e4438b4ad006a55a6b753 |
| Source note | uspto-grants-2001_10 |