HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → (E)-2-(3-Methyl-1-butenyl)-5-methoxy-1-(2-pyridyl)-1H-benzimidazole oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Reactant | (E)-4-methylpent-2-enoyl Chloride | HCID 10986269 | — |
| Reactant | 2-amino-4-methoxy-N-(2-pyridyl)aniline | HCID 22736653 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (E)-2-(3-Methyl-1-butenyl)-5-methoxy-1-(2-pyridyl)-1H-benzimidazole oxalate | HCID 22736729 | — |
Reaction Steps
Free base of the titled compound was prepared from 4-methoxy-2-amino-N-(2-pyridyl)aniline and (E)-4-methyl-2-pentenoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310079B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-17e2e97ba1dc461d9e850b4285f04593 |
| Source note | uspto-grants-2001_10 |