HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → (2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-6-hydroxyacetophenone | HCID 74061 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2-acetyl-4-chlorophenoxy)-acetic Acid, 1,1-dimethylethyl Ester | HCID 67131695 | — |
Reaction Steps
A mixture of 1-(5-chloro-2-hydroxyphenyl)-ethanone (2 g), potassium carbonate (1.62 g) and tert-butylbromoacetate (1.73 ml) in DMF (5 ml) was stirred at ambient temperature for 16 h. Diethyl ether and water were added and the organic layer separated, it was washed with water, aqueous potassium carbonate solution, brine, dried (Na2SO4) and the solvent removed in vacuo to give the sub-title compound (2.84 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524715B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-e58e506d526849c4b183a9ac5b1d2265 |
| Source note | uspto-grants-2013_09 |