Imidazole → HCID 18360047, compound

Participants

Reaction Steps

To a solution of 2.42 mg of 7-hydroxymethylimidazo[5,1-b]thiazole in 15 ml of DMF were added under ice-cooling 1.4 g of imidazole and 2.73 g of t-butyldimethylsilylchloride, and the mixture was stirred at the same temperature for 2 hours. DMF was removed under reduced pressure, and the residue was extracted two times with ethyl acetate. The organic layer was washed two times with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and removed under reduced pressure to give 7-(t-butyldimethylsilyloxy)methylimidazo[5,1-b]thiazole in a yield of 4.02 g.

Provenance & Evidence