Phosphate → HCID 178462289, compound

Participants

Reaction Steps

To a solution of 58 mg of 4-nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl)-2-(6-methylimidazo[5,1-b]thiazolium-2-yl)-1-carbapen-2-em-3-carboxylate iodide in 2 ml of THF and 2 ml of 1/15 M phosphate buffer (pH 6.8) was added 68 mg of 10% Pd-C. The reactor was purged with hydrogen, and the reaction mixture was stirred at room temperature for 4 hours. The catalyst was collected by filtration on Celite, and washed with water. The filtrate was washed with ethyl acetate, the aqueous layer was purified by column chromatography on DIAION HP-20 to give 5.4 mg of the title compound.

Provenance & Evidence