反应详情

To a suspension of 69 mg of 4-nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl)-2-(imidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate in 2 ml of acetone was added 281 mg of iodoacetamide, and the mixture was stirred at room temperature for 25 hours. The reaction mixture was concentrated under reduced pressure to dryness. The residue was triturated with 3 ml of ethyl acetate, and the insolubles were collected by filtration to give 4-nitrobenzyl (5R,6S)-2-(6-carbamoylmethylimidazo[5,1-b]thiazolium-2-yl)-6-((1R)-1-hydroxyethyl)-1-carbapen-2-em-3-carboxylate iodide.

1. concentrationThe reaction mixture was concentrated under reduced pressure to dryness
2. customThe residue was triturated with 3 ml of ethyl acetate
3. filtrationthe insolubles were collected by filtration