Phenylacetyl chloride → [4-chloro-2-[4-(phenylacetyl)-1-piperazinyl]phenoxy]-acetic Acid

HRID 38265Notes

Reaction equation

HRID 38265 reaction equation
Cl.[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([O:11]CC)=[O:10])=[C:5]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH:4]=1.[C:22]1([CH2:28][C:29](Cl)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[Cl:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([OH:11])=[O:10])=[C:5]([N:16]2[CH2:17][CH2:18][N:19]([C:29](=[O:30])[CH2:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:21]2)[CH:4]=1

Participants

3

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 86631058[4-chloro-2-(1-piperazinyl)phenoxy]-acetic Acid, Ethyl Ester Hydrochloride Salt

Product 1

HCID 11523933[4-chloro-2-[4-(phenylacetyl)-1-piperazinyl]phenoxy]-acetic Acid

Procedure

Prepared from the product from example 38 step c) and benzeneacetyl chloride by the method of Example 38 step d) to give the title compound as a white solid.

Sources & evidence

ORD record
ord-2f20323e1b6f47f5ad5c41d41bb62fa7
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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