HCID 131722925, compound → HCID 131722930, compound

Participants

Reaction Steps

To a solution 428 mg of 4-nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-hydroxymethylimidazo[5,1-b]thiazol-3-yl)-1-carbapen-2-em-3-carboxylate in 30 ml of dichloromethane was added 1.03 g of manganese dioxide, and the mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue thus obtained was washed with diethyl ether to give 202.8 mg of 4-nitrobenzyl (5R,6S)-2-(7-formylimidazo[5,1-b]thiazol-3-yl)-6-((1R)-1-hydroxyethyl)-1-carbapen-2-em-3-carboxylate.

Provenance & Evidence