Phenylacetyl chloride → [4-Chloro-2-[[3-methyl-4-(phenylacetyl)-1-piperazinyl]methyl]phenoxy]acetic Acid
Reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](S(CC3C=CC=CC=3)(=O)=O)[CH:16]([CH3:30])[CH2:15]2)[CH:3]=1.[C:31]1([CH2:37][C:38](Cl)=[O:39])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:38](=[O:39])[CH2:37][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH:16]([CH3:30])[CH2:15]2)[CH:3]=1Participants
3
Procedure
Prepared by the method of example 30, using the product from example 56 part (a) and benzeneacetyl chloride to give the title compound.
Workup
- customPrepared by the method of example 30
Sources & evidence
- ORD record
- ord-3a5fef43c3064f2ca8a85491525cb85d
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524715B2
Reaction notes
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