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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 3827Generated: October 29, 2026

1-Bromo-3-chloropropane → 1-[3-(4-Chlorophenyl)propyl]-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/reaction/3827

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant1-(3-(4-Chlorophenyl)propyl)piperazineHCID 162873—
SolventDimethyl SulfoxideHCID 679—
Product1-[3-(4-Chlorophenyl)propyl]-4-(3-chloropropyl)piperazine dihydrochlorideHCID 20153180104.9%

Reaction Steps

The procedure described in Example 17(a) was followed, using 27.0 g of 3-(4-chlorophenyl)propyl piperazine, 22.0 g of potassium hydroxide, 250 ml of dimethyl sulfoxide and 17.7 g of 1-bromo-3-chloropropane to give 22.9 g (54% of theory) of 1-[3-(4-chlorophenyl)propyl]-4-(3-chloropropyl)piperazine dihydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04722926
Source datasetuspto-grants-1988_02
ORD IDord-ad02dc0d397f4092b422fb887e5d9b33
Source noteuspto-grants-1988_02