HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 86631061, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-ethyl-1-piperazinecarboxylic Acid, 1,1-Dimethylethyl Ester | HCID 86631063 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86631061 | HCID 86631061 | — |
Reaction Steps
To a solution of the product from example 69 part e) (2 g) in dichloromethane (100 ml) was added trifluoroacetic acid (100 ml). The mixture was stirred at RT for 24 h. Toluene (100 ml) was added and reaction was concentrated (bath temp <40° C.) in vacuo to give the sub-titled compound as a yellow oil (3.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524715B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-8fbf0b57f1e3419084f20b26f3e4e81f |
| Source note | uspto-grants-2013_09 |