HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- → (R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionic acid (3S,4S)-1,4-dibenzyl-piperidin-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- | HCID 2724611 | — |
| Reactant | (3SR,4SR)-1,4-dibenzyl-piperidin-3-ol | HCID 18175381 | — |
| Product | (R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionic acid (3S,4S)-1,4-dibenzyl-piperidin-3-yl ester | HCID 57201513 | 29% |
Reaction Steps
The title compound was prepared from (3SR,4SR)-1,4-dibenzyl-piperidin-3-ol and (S)-(+) -alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride in 29% yield as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310213B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-18a730e601f8441da1c0f52e3d27274b |
| Source note | uspto-grants-2001_10 |