HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- → (R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionic acid (cis)-1-benzyl-4-(4-methyl-benzyl)-piperidin-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- | HCID 2724611 | — |
| Reactant | (3SR,4SR)-4-(4-methyl-benzyl)-piperidin-3-ol | HCID 18362020 | — |
| Product | (R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionic acid (cis)-1-benzyl-4-(4-methyl-benzyl)-piperidin-3-yl ester | HCID 59972010 | 36% |
Reaction Steps
The title compound was prepared from (3SR,4SR)-4-(4-methyl-benzyl)-piperidine-3-ol and (S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride in 36% yield as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310213B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-f9fe7c91c296409ca4657129fa1cc062 |
| Source note | uspto-grants-2001_10 |