1-Bromopropane → HCID 18361928, compound

HRID 382817Notes

Reaction equation

HRID 382817 reaction equation
[CH3:1][C:2]1[C:7]2[C:8](=[O:16])[CH2:9][CH:10]3[CH:15]([C:6]=2[CH:5]=[C:4]([CH3:17])[CH:3]=1)[CH2:14][NH:13][CH2:12][CH2:11]3.Br[CH2:19][CH2:20][CH3:21]>>[CH3:1][C:2]1[C:7]2[C:8](=[O:16])[CH2:9][CH:10]3[CH:15]([C:6]=2[CH:5]=[C:4]([CH3:17])[CH:3]=1)[CH2:14][N:13]([CH2:19][CH2:20][CH3:21])[CH2:12][CH2:11]3

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 18361907HCID 18361907, compound

Product 1

HCID 18361928HCID 18361928, compound

Procedure

In an analogous manner to that described in Example 49 b), from (+)-7,9-dimethyl-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one by alkylation with bromopropane there was obtained (+)-7,9-dimethyl-2-propyl-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one, which was converted with fumaric acid into the fumarate (1:1) with m.p. 220.5-226.50°, [α]589=+33.7 (c=0.5, H2O).

Sources & evidence

ORD record
ord-4e31cb5c7e4542f19d06331e974b5ab0
Source dataset
uspto-grants-2001_10
Patent number
US06310208B1

Reaction notes

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