HCID 18361973, compound → HCID 18361907, compound

Participants

Reaction Steps

a 2.2) 250 mg of Zn powder were added to a solution of 890 mg (2.2 mmol) of 2,2,2-trichloroethyl 7,9-dimethyl-6-oxo-3,4,4a,5, 6,10b-hexahydro-1H-benzo[h]isoquinoline-2-carboxylate in 10 ml of glacial acetic acid and the mixture was stirred at room temperature for 16 hrs. The solution was filtered and adjusted to pH 10 with 28% NaOH. The aqueous phase was extracted twice with the 30 ml of methylene chloride, dried (Na2SO4), filtered and evaporated. Chromatography of the residue (silica gel, methylene chloride/methanol/NH4OH 200:10:1) yielded 420 mg (83%) of 7,9-dimethyl-1,3,4,4a,5,10b-hexahydro-2H-benzo[h]isoquinolin-6-one as a colorless oil.

Provenance & Evidence