HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dodecanoyl chloride | HCID 8166 | — |
| Reactant | 1H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl ester | HCID 137477 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate | HCID 18362055 | — |
Reaction Steps
1.46 g (11 mmol) of AlCl3 were added to a solution of 1.67 g (10 mmol) of ethyl 3,5-dimethylpyrrole-2-carboxylate a 2.63 g (12 mmol) of dodecanoyl chloride in 30 ml of absol. Dichloromethane and then stirred for 24 h. Addition of water and dilute HCl is followed by extraction twice with CH2Cl2. The organic phases are washed with dilute NaOH, dried over Na2SO4 and concentrated. The product is recrystallized from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310217B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-85823facb44a4b2297b82673efd223d8 |
| Source note | uspto-grants-2001_10 |