Phenylacetyl chloride → [4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

HRID 38283Notes

Reaction equation

[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](S(C3C=CC=CC=3)(=O)=O)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1.[C:32]1([CH2:38][C:39](Cl)=[O:40])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:39](=[O:40])[CH2:38][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 11597936HCID 11597936, compound

Product 1

HCID 11539557[4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

Procedure

Prepared from the product from example 72 part (f) (0.70 g) and phenylacetyl chloride according to the procedure described in example 69 part (g) to give the title compound as a white solid (214 mg).

Sources & evidence

ORD record: ord-0362b148b29e4e6a8d6012284df9cda1
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08524715B2

Reaction notes

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