Phenylacetyl chloride → HCID 86631066, compound

HRID 38284Notes

Reaction equation

HRID 38284 reaction equation
[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:3]1.[C:16]1([CH2:22][C:23](Cl)=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:8][C@H:6]1[N:7]([C:23](=[O:24])[CH2:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C@@H:2]([CH3:1])[CH2:3][N:4]([C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10])[CH2:5]1

Participants

3

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 10822535tert-butyl (3R,5S)-3,5-dimethylpiperazine-1-carboxylate

Product 1

HCID 86631066HCID 86631066, compound

Procedure

Prepared by the method of example 67 part (a) using (3R,5S)-3,5-dimethyl-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester and phenyl acetyl chloride to give the sub-title compound.

Sources & evidence

ORD record
ord-e7091d114b1c4a9aaff93d27c0f7f09c
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

Loading…