Hydrochloric Acid → HCID 11163742, compound

Participants

Reaction Steps

Ethanol (200 ml) was added to 20.0 g of (7α,20S)-7-hydroxy-3-oxo-pregna-1,4-diene-20-carbaldehyde. To this solution was added 0.61 g of sodium borohydride in several portions with stirring under ice cooling. After completion of the addition, the mixture was further stirred for 1 hour under ice cooling. The reaction mixture was neutralized with 1 N hydrochloric acid, then 200 ml of water was added, and the ethanol was distilled off under reduced pressure. The precipitate was collected by filtration, washed with water, then dehydrated by adding toluene to the precipitate and removing water by azeotropic distillation, and concentrated to give 18.8 g of (7α,20S)-7,21-dihydroxy-20-methyl-pregna-1,4-dien-3-one (yield 93%).

Provenance & Evidence