HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzylamine → HCID 18372562, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | 5-Chloro-8-hydroxyquinoline-7-carboxylic acid | HCID 14534767 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18372562 | HCID 18372562 | 32.1% |
Reaction Steps
To a solution of 5-chloro-8-hydroxyquinoline-7-carboxylic acid (0.335 g) of Preparation 3 and 4-chlorobenzylamine (0.219 g) in 20 mL DMF is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.305 g) and 1-hydroxybenzotriazole monohydrate (0.217 g). The mixture is stirred overnight. The solution is then poured into 30 mL ice-water. The resulting solid is collected and dried to yield 0.167 g of the title product as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310211B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-e882356f70e542168a513059f79d6277 |
| Source note | uspto-grants-2001_10 |