(1-Methyl-1H-1,2,4-triazol-3-yl)methanol → 3-(5-Fluoromethylisoxazol-3-yl)-6-(1-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Beteiligte Stoffe

Reaktionsschritte

Prepared from the product of Example 66 part c (85 mg, 0.28 mmol) and 3-hydroxymethyl-1-methyl-1,2,4-triazole using the method of Example 1 to yield a pale yellow solid (56 mg, 52%), 1H NMR (360 MHz, CDCl3) δ 3.96 (3H, s), 5.58 (2H, d, J=44 Hz), 5.73 (2H, s), 7.51 (1H, s), 7.81 (1H, J=7 Hz), 7.96 (1H, t, J=7 Hz), 8.08 (1H, s), 8.30 (1H, d, J=7 Hz), 8.72 (1H, d, J=7 Hz); MS (ES+) m/e 381 [MH]+.

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