HCID 18361764, compound → HCID 18361844, compound

HRID 382940Notes

Reaction equation

HRID 382940 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[CH:19]=[CH:18][O:17][N:16]=3)[N:4]2[N:3]=1.[CH2:20]([N:23]1[CH:27]=[N:26][C:25]([CH2:28][OH:29])=[N:24]1)[CH2:21][CH3:22]>>[O:17]1[CH:18]=[CH:19][C:15]([C:14]2[N:4]3[N:3]=[C:2]([O:29][CH2:28][C:25]4[N:26]=[CH:27][N:23]([CH2:20][CH2:21][CH3:22])[N:24]=4)[C:11]4[C:6]([C:5]3=[N:12][N:13]=2)=[CH:7][CH:8]=[CH:9][CH:10]=4)=[N:16]1

Participants

3

Reactant 2

HCID 18361764HCID 18361764, compoundHCID 183617991-Propyl-1H-1,2,4-triazole-3-methanol

Product 1

HCID 18361844HCID 18361844, compound

Procedure

The title-compound was prepared from 6-chloro-3-(isoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine (described in Example 34 part b) and 1-propyl-3-hydroxymethyl-1,2,4-triazole prepared as described in WO-A-9804559 using the procedure given for Example 71, 1H NMR (360 MHz, CDCl3) δ 0.95 (3H, t, J=7.4 Hz, CH3), 1.89-1.99 (2H, m, CH2), 4.15 (2H, t J=7.0 Hz, CH2), 5.73 (2H, s, CH2), 7.40 (1H, d, J=1.7 Hz, Ar—H), 7.80 (1H, t, J=7.2 Hz, Ar—H), 7.96 (1H, t, J=6.9 Hz, Ar—H), 8.09 (1H, s, Ar—H), 8.28 (1H, d, J=7.9 Hz, Ar—H), 8.70 (1H, s, Ar—H), 8.74 (1H, d, J=7.7 Hz, Ar—H); MS (ES+) m/e 377 [MH]+.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-ab78bb4f1278413aa6d0f1a65c3cf734
Source dataset
uspto-grants-2001_10
Patent number
US06310203B1

Reaction notes

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