(1-methyl-1H-1,2,4-triazol-5-yl)methanol → 3-(5-Methoxymethylisoxazol-3-yl)-6-(2-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Participants

Reaction Steps

The title-compound was prepared from the product of Example 116 part a and 1-methyl-1,2,4-triazole-5-methanol (prepared using the conditions of Itoh and Okongi, EP-A-421210) in a similar manner to Example 98, mp 206-207.56° C.; 1H NMR (360 MHz, CDCl3) δ 3.53 (3H, s, CH3), 4.12 (3H, s, CH3), 4.73 (2H, s, CH2), 5.87 (2H, s, CH2), 7.20 (1H, s, ArH), 7.42 (1H, s, ArH), 7.93 (1H, m, ArH), 8.06 (1H, m, ArH), 8.30 (1H, d, J=7.7 Hz, ArH), 8.70 (1H, d, J=7.2 Hz, ArH); MS (ES+) m/e 393 [MH]+.

Provenance & Evidence