6-Methyl-2-pyridylmethanol → 3-(3-Methylisoxazol-5-yl)-6-(6-methylpyridin-2-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

HRID 382943Notes

Reaction equation

HRID 382943 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1.[CH3:28]C1N=C(CO)C=CC=1>>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[N:23]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1

Participants

3

Reactant 2

HCID 707366-Methyl-2-pyridylmethanolHCID 183618903-(3-Methylisoxazol-5-yl)-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Product 1

HCID 183618083-(3-Methylisoxazol-5-yl)-6-(6-methylpyridin-2-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Procedure

The title-compound was prepared from the product of Example 120, step a, and 6-methyl-2-pyridylcarbinol using the procedure given for Example 1, 1H NMR (360 MHz, CDCl3) δ 2.48 (3H, s, CH3), 2.64 (3H, s, CH3), 5.74 (2H, s, CH2), 7.07 (1H, s, Ar—H), 7.18 (1H, d, J=7.7 Hz, Ar—H), 7.44 (1H, d, J=7.6 Hz, Ar—H), 7.69 (1H, t, J=7.7 Hz, Ar—H), 7.85 (1H, m, Ar—H), 7.99 (1H, m, Ar—H), 8.35 (1H, d, J=8.6 Hz, Ar—H), 8.71 (1H, d, Ar—H); MS (ES+) m/e 373 [MH]+.

Sources & evidence

ORD record
ord-301ad5354c3a462eb0a1c26a5518b316
Source dataset
uspto-grants-2001_10
Patent number
US06310203B1

Reaction notes

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