Pyrazine, 2-(chloromethyl)- → 3-(3-Methylisoxazol-5-yl)-6-(pyrazin-2-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

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Reaction Steps

The title-compound was prepared from 6-hydroxy-3-(3-methylisoxazol-5-yl)-1,2,4-triazolo[3,4-a]phthalazine (generated from the product of Example 120 part a using the conditions described for the preparation of Intermediate 2) and 2-chloromethylpyrazine (prepared as described in Example 15 part a) using the procedure described in Example part b. 1H NMR (360 MHz, CDCl3) δ 2.48 (3H, s, CH3), 5.83 (2H, s, CH2), 7.03 (1H, s, Ar—H), 7.87 (1H, m, Ar—H), 8.01 (1H, m, Ar—H), 8.32 (1H, d, J=7.8 Hz, Ar—H), 8.62-8.68 (2H, m, 2 of Ar—H), 8.72 (1H, d, J=7.8 Hz, Ar—H), 8.99 (1H, s, Ar—H); MS (ES+) m/e 360 [MH]+; Anal. Found C, 60.24; H, 3.44; N, 27.03. C18H13N7O2 requires C, 60.16; H, 3.63; N, 27.28%.

Provenance & Evidence