反应详情

The title-compound was prepared from the product of Example 120 part a and 3-hydroxymethyl-1-methyl-1,2,4-triazole (prepared using the conditions of Itoh and Okongi, EP-A-421210) following the conditions described for Example 71, mp 270-271.5° C.; 1H NMR (360 MHz, CDCl3) δ 2.50 (3H, s, CH3), 3.97 (3H, s, CH3), 5.73 (2H, s, CH2), 7.31 (1H, s, Ar—H), 7.82 (1H, m, Ar—H), 7.97 (1H, m, Ar—H), 8.09 (1H, s, Ar—H), 8.31 (1H, d, J=8.6 Hz, Ar—H), 8.70 (1H, d, J=8.6 Hz, Ar—H); MS (ES+) m/e 363 [MH]+; Anal. Found. C, 55.92; H, 3.63; N, 30.16. C17H4N8O2. 0.06CH2Cl2 requires C, 55.77; H, 3.87, N, 30.49%.

1. customprepared