4-Methoxyphenylacetyl chloride → HCID 11633718, compound

HRID 38297Notes

Reaction equation

HRID 38297 reaction equation
ClC1C=C[C:5]([O:6]CC(OC(C)(C)C)=O)=C(CN(C)C2CCN(S(C3C=CC=CC=3)(=O)=O)C2)C=1.[Cl:34][C:35]1[CH:45]=[CH:44][C:38]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:37]([CH2:46][N:47]2[CH2:52][CH2:51][N:50]([C:53](=[O:62])[CH2:54][C:55]3[CH:60]=[CH:59][C:58](F)=[CH:57][CH:56]=3)[C@@H:49]([CH3:63])[CH2:48]2)[CH:36]=1.ClC1C=CC(OCC(OC(C)(C)C)=O)=C(COS(C)(=O)=O)C=1.COC1C=CC(CC(Cl)=O)=CC=1>>[Cl:34][C:35]1[CH:45]=[CH:44][C:38]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:37]([CH2:46][N:47]2[CH2:52][CH2:51][N:50]([C:53](=[O:62])[CH2:54][C:55]3[CH:60]=[CH:59][C:58]([O:6][CH3:5])=[CH:57][CH:56]=3)[C@@H:49]([CH3:63])[CH2:48]2)[CH:36]=1

Participants

5

Reactant 4

HCID 27346884-Methoxyphenylacetyl chlorideHCID 11633473[4-chloro-2-[[(3S)-4-[(4-fluorophenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]-acetic AcidHCID 86631070[4-chloro-2-[[(methylsulfonyl)oxy]methyl]phenoxy]-acetic Acid, 1,1-dimethylethyl EsterHCID 86631075HCID 86631075, compound

Product 1

HCID 11633718HCID 11633718, compound

Procedure

The title compound was prepared by the methods of example 89 part (f) and example 89 part (g) using the product of example 89 part (e) and 4-methoxy-benzeneacetyl chloride.

Sources & evidence

ORD record
ord-5da2c33f89714313b2cc2cce9bc15c35
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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