Acetoxyacetyl chloride → HCID 18429273, compound

HRID 383026Notes

Reaction equation

[OH:1][CH:2]([C:5]1[C:10]([I:11])=[C:9]([NH2:12])[C:8]([I:13])=[C:7]([NH2:14])[C:6]=1[I:15])[CH2:3][OH:4].C([O:19][CH2:20][C:21](Cl)=[O:22])(=O)C>>[OH:1][CH:2]([C:5]1[C:6]([I:15])=[C:7]([NH:14][C:2](=[O:1])[CH2:3][OH:4])[C:8]([I:13])=[C:9]([NH:12][C:21](=[O:22])[CH2:20][OH:19])[C:10]=1[I:11])[CH2:3][OH:4]

Participants

Reactant 2

HCID 26297Acetoxyacetyl chloride

HCID 18429214HCID 18429214, compound

Product 1

HCID 18429273HCID 18429273, compound

Procedure

1-(1,2-Dihydroxyethyl)-3,5-diamino-2,4,6-triiodobenzene is acylated with acetoxyacetyl chloride using for example such a procedure as described in Example 4d. The crude product is then hydrolyzed analogous to Example 4e to give the final product. Purification of the crude product is carried out using preparative HPLC.

Sources & evidence

ORD record: ord-4a68e57de9ff42b69a81357c889c88b8
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310243B1

Reaction notes

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