反应详情

5-Amino-3-hydroxymethyl-2,4,6-triiodobenzoic acid (41.2 g, 0.076 mol) was dissolved in pyridine (100 ml), and acetic anhydride (80 ml) was added slowly with efficient stirring at room temperature. Stirring was continued overnight. The reaction mixture was then evaporated to a semisolid mass and treated with hydrochloric acid (2M, 250 ml). The white to grey precipitate formed was filtered off and washed with water (2×40 ml) and then dried. 44.2 g (100%) of product was isolated.

1. stirringStirring
2. customThe reaction mixture was then evaporated to a semisolid mass
3. additiontreated with hydrochloric acid (2M, 250 ml)
4. customThe white to grey precipitate formed
5. filtrationwas filtered off
6. washwashed with water (2×40 ml)
7. customdried