Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Acetoxypropionyl Chloride → 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Acetoxypropionyl Chloride | HCID 4547492 | — |
| 반응물 | 3-Acetoxymethyl-5-(2,3-diacetoxypropylaminocarbonyl)-2,4,6-triiodoaniline | HCID 18429130 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide | HCID 18429188 | 100% |
반응 단계
5-Amino-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (3.20 g, 4.3 mmol) was dissolved in dry dimethylacetamide (4 ml). 2-Acetoxypropionyl chloride (2.17 ml, 17.2 mmol) was then added dropwise with efficient stirring. Stirring was continued over night. After work up according to the procedure in Example 24i, 3.66 g (100%) of product was isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310243B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-1d2e02de960d42468d097c0e4628acfe |
| 출처 메모 | uspto-grants-2001_10 |