4-Amino-3-methylbenzoic acid → 4-{[(Tert-butoxy)carbonyl]amino}-3-methylbenzoic acid

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Reaction Steps

4-Amino-3-methylbenzoic acid (5 g, 33.1 mmol) was reacted according to the same procedure as that used in the process for preparing N-BOC-4-aminobenzoic acid. The resulting orange-brown solid was recrystallized from ethyl acetate and hexanes to provide the desired product (4.99 g) as tan prismatic crystals: m.p. 180-182° C.;

Provenance & Evidence