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HRID383082

反应详情

EQUATION

反应方程式

HRID 383082 的结构方程式

REACTANTS

反应物

5
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：COC(=O)[C@@H](N)CCSC
HCID64684

Methyl L-methioninate

C6H13NO2S

结构：Br.Brc1ccccn1
HCID23436281

2-Bromopyridine--hydrogen bromide (1/1)

C5H5Br2N

结构：COC(=O)c1ccc(S)cc1-c1ccccc1
HCID54364019

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](CCSC)NC(=O)c1ccc(Sc2ccccn2)cc1-c1ccccc1
HCID20622789

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of the resultant thiophenol from Example 12A (1.0 equivalent) is treated with 2-bromopyridine hydrobromide (1.0 equivalent) in the presence of a NaH (2.0 equivalents), or K2CO3 (3.0 equivalents) in DMF or pyridine. The product is isolated by removal of the solvent and chromatography on silica gel. The resultant ester is hydrolyzed according to the procedure of Example 6C and then is coupled to methionine methyl ester according to the procedure of Example 1C to give the title compound.

WORKUP

后处理

  1. customThe product is isolated by removal of the solvent and chromatography on silica gel