methyl (2S)-2-amino-4-(methylsulfanyl)butanoate → 4-(2-Pyridylsulfonyl)-2-phenylbenzoylmethionine methyl ester

HRID 383083Notes

Reaction equation

HRID 383083 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([C:10]1[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[C:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:11]=1)(=[O:9])=[O:8].[CH3:25][O:26][C:27](=[O:34])[C@H:28]([CH2:30][CH2:31][S:32][CH3:33])[NH2:29]>>[CH3:25][O:26][C:27](=[O:34])[C@H:28]([CH2:30][CH2:31][S:32][CH3:33])[NH:29][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][C:10]([S:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)(=[O:9])=[O:8])=[CH:11][C:12]=1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 64684methyl (2S)-2-amino-4-(methylsulfanyl)butanoateHCID 234362424-(2-Pyridylsulfonyl)-2-phenylbenzoic acid

Product 1

HCID 206227884-(2-Pyridylsulfonyl)-2-phenylbenzoylmethionine methyl ester

Procedure

The resultant product from Example 14B is coupled to methionine methyl ester according to the procedure of Example 1C to give the title compound.

Sources & evidence

ORD record
ord-c487a06695ea43cb8062cddfc8d0b7c8
Source dataset
uspto-grants-2001_10
Patent number
US06310095B1

Reaction notes

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