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Water → 2-Phenylterephthalic acid mono methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tesmilifene Hydrochloride | HCID 175534 | — |
| 反応物 | Methyl 5-bromo-[1,1'-biphenyl]-2-carboxylate | HCID 54332024 | — |
| 反応物 | HCID 178418416 | HCID 178418416 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Phenylterephthalic acid mono methyl ester | HCID 85732474 | — |
反応手順
A solution of 4-bromo-2-phenylbenzoic acid methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310095B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-f0055115cea34ce39d0c62f7bbdd8256 |
| 出典メモ | uspto-grants-2001_10 |