HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl morpholine oxide → 4-Formyl-2-phenylbenzoyl methionine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | [4-Hydroxymethyl-2-phenylbenzoyl]methionine methyl ester | HCID 20622833 | — |
| Reactant | Acetonitrile methylene chloride | HCID 21877088 | — |
| Catalyst | HCID 178419074 | HCID 178419074 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Formyl-2-phenylbenzoyl methionine methyl ester | HCID 10571267 | — |
Reaction Steps
A mixture of the resultant alcohol from Example 16D (1.0 equivalent), N-methylmorpholine-N-oxide (1.5 equivalents), molecular sieves, and a catalytic amount of TPAP is stirred in a CH2Cl2/acetonitrile mixture until the reaction is judged complete by TLC analysis. The mixture is diluted with ethyl ether and filtered through SiO2. The product is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310095B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-7f0dc77046ef4b72ab1cd90fccc4f87a |
| Source note | uspto-grants-2001_10 |