HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 383099Generated: October 25, 2026
Diethylamine → {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester
https://huagongshe.com/reaction/383099
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | (4-Ethynyl-2-phenylbenzoyl)methionine methyl ester | HCID 54338681 | — |
| Reactant | HCID 178418934 | HCID 178418934 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester | HCID 69930468 | — |
Reaction Steps
The resultant product from Example 47A (5 mmol) is mixed with 4-bromoimidazole (5 mmol), diethylamine (1 mL), bis(triphenylphosphine) palladium diacetate (0.1 mmol) and copper(I) iodide (0.1 mmol) in toluene. The mixture is stirred at 25° C. until TLC analysis indicates the reaction is complete. The reaction mixture is concentrated in vacuo, and the residue is purified with column chromatography on silica gel to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06310095B1 |
|---|
| Source dataset | uspto-grants-2001_10 |
|---|
| ORD ID | ord-04fbeb321b1942278ce4c827379db58d |
|---|
| Source note | uspto-grants-2001_10 |
|---|
