反应详情

1.2 g of phenyl isocyanate was added to a solution of 2.5 g of 3-[4-(4-fluorophenyl)piperazin-1-yl]propanethiol in 75 ml of methylene chloride, and the mixture was refluxed for four hours. After the further addition of 100 ml of methylene chloride the solution was washed with water, dried (sodium sulfate) and concentrated. The salt was precipitated with ethereal hydrochloric acid and recrystallized from aqueous ethanol to give 1.35 g (33% of theory) of N-phenyl-S-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 250°-252° C.

1. temperaturethe mixture was refluxed for four hours
2. washwas washed with water
3. dry with materialdried (sodium sulfate)
4. concentrationconcentrated
5. customThe salt was precipitated with ethereal hydrochloric acid
6. customrecrystallized from aqueous ethanol