Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Carboxy-2-phenylbenzoyl methionine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tesmilifene Hydrochloride | HCID 175534 | — |
| 반응물 | (2-Phenyl4bromobenzoyl)-methionine methyl ester | HCID 20622824 | — |
| 반응물 | HCID 178418416 | HCID 178418416 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Carboxy-2-phenylbenzoyl methionine methyl ester | HCID 20622825 | — |
반응 단계
A solution of 4-bromo-2-phenylbenzoyl methionine methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310095B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-089535082d7644e9af225ebee1e117c6 |
| 출처 메모 | uspto-grants-2001_10 |