Ammonia → HCID 20622821, compound

HRID 383107Notes

Reaction equation

HRID 383107 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:24][CH2:25][S:26][CH3:27])[NH:5][C:6](=[O:23])[C:7]1[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][C:8]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[NH3:29]>ClCCl>[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:24][CH2:25][S:26][CH3:27])[NH:5][C:6](=[O:23])[C:7]1[CH:12]=[CH:11][C:10]([S:13]([NH2:29])(=[O:15])=[O:14])=[CH:9][C:8]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20622827HCID 20622827, compound

Product 1

HCID 20622821HCID 20622821, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-chlorosulfonyl-2-phenylbenzoyl methionine methyl ester from Example 5E in dichloromethane is added aqueous ammonia and the mixture is stirred until the reaction is judged complete by TLC analysis. The organic phase is separated, dried and evaporated and the product is purified by chromatography on silica gel.

Workup

  1. customThe organic phase is separated
  2. customdried
  3. customevaporated
  4. customthe product is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-338f7b77914f41909c32ce9ffdc47e00
Source dataset
uspto-grants-2001_10
Patent number
US06310095B1

Reaction notes

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